Brin Beyer

  • Clinical metastases at presentation and poor ECOG performance status were the strongest predictors of poor OS on multivariable analysis (Table 2). Previous studies have demonstrated that patients with RCC who have advanced tumor thrombus and clinical metastases at presentation have dramatically inferior OS when compared with that of patients…[Read more]

  • There are several limitations in our study. We chose dogs as experimental animals because larger animals are more appropriate for retroperfusion. In addition to their higher cost, pigs are vulnerable to ventricular fibrillation when modeling and suffer mortality of 50%, whereas smaller laboratory animals, such as mice, are difficult to recover…[Read more]

  • Routinely the literature states that ‘the mechanism of LIPUS has yet to be elucidated’. We believe that there is evidence supporting both a credible mode and a mechanism behind the LIPUS technology. ‘Mode’ is described in dictionaries as ‘a way in which something occurs or is done’ [23]. Therefore the mode of action that we propose for how LIP…[Read more]

  • As can be seen from the cover of this issue, has a new Co-Editor-in-Chief, , who has joined the editorial team as successor to Jan Naessens, who has stepped down as Co-Editor after more than 15 years of service in this role. We would like to extend our sincere thanks to Jan for the excellent work that he has done as Co-Editor-in-Chief during…[Read more]

  • NMI Tunicamycin cancer and variant histologiesFor UC with variant histologies, the incidence of NMI tumors is approximately 20% to 30% with many of these lesions being of high grade and cT1 stage [15,16]. Analysis of the Netherlands Cancer Registry between 1995 and 2006 by Ploeg et al. [15] identified more than 28,000 cases of T1 or greater…[Read more]

  • There exists controversy over the relationship between liver function and HV waveform pattern. Some studies have reported that liver function tends to worsen in cases with a flat pattern (Bolondi et al. 1991; Kawanaka et al. 2008), whereas another study found no significant relationship between HV waveform pattern and liver function (Sudhamshu e…[Read more]

  • It should be noted though that some practical difficulties linked to the MCMC approach need to be considered. It is indeed quite inefficient, as it typically requires thousands of iterations. Without efficient forward modeling, computing the solution may take a very long time. In the examples of this paper, an analytical sensitivity kernel was…[Read more]

  • Current PEDIG RCTs in amblyopiaPEDIG is currently completing a study of patching 2h per day with levodopa versus patching 2h per day with placebo, and another study of adding a plano lens to atropine treatment in children whose amblyopia eye visual acuity stops improving when using atropine alone in the fellow eye. Results of these two studies are…[Read more]

  • Interestingly, after single ESWT, a decrease in inflammatory reactions was detectable on days 10 and 35 only, whereas tubocurarine thickness persisted until day 100. Therefore, initial suppression of inflammation inhibited further growth of the fibrous envelope. This conclusion was substantiated by the significant decrease in TGFβ-1 expression. R…[Read more]

  • Results and discussionConclusionsIn this study, the size distribution of ultrasonic mists generated at different frequencies was investigated. We focused on the generation mechanism of ultrasonic nanosized mist based on the relation between the size distribution of the mist and the ultrasonic frequency. The effect of the ultrasonic energy on the…[Read more]

  • Brin Beyer posted an update 3 months ago

    The etiology of post-RP UI is not completely understood, but it primarily results from sphincter insufficiency, detrusor overactivity, reduced LY335979 Supplier compliance, and decreased contractility. Prognostic factors for post-RP UI include age, previous bladder surgery, nerve-sparing status, anastomotic stricture, and surgical…[Read more]

  • Brin Beyer posted an update 3 months ago

    To the best of our knowledge, it is the first report on the use of recombinant BgP12 in dot-ELISA format for detection of LDE225 to B. gibsoni in dogs. In summary, we demonstrated that ELISA and dot ELISA with the rBgP12 have high sensitivities and reliable specificities for detection of specific antibodies without showing cross reactivity.…[Read more]

  • Brin Beyer posted an update 3 months ago

    Luteinizing hormone–releasing hormone antagonists like degarelix has potential inherent advantages like avoiding testosterone flare and has been approved by the Food and Drug Administration for the treatment of advanced prostate cancer in 2008 based on a Phase III study showing that degarelix was at least as effective as leuprolide in sustaining c…[Read more]

  • Brin Beyer posted an update 3 months ago

    Non-invasive methods that measure the degree of liver fibrosis or spleen stiffness (SS) have recently been developed. Transient elastography (TE) is considered a non-invasive method to evaluate PH (de Franchis and Baveno VI Faculty 2015). While applicability of liver stiffness (LS) and SS by TE are suboptimal because of technical limitations…[Read more]

  • Brin Beyer posted an update 3 months ago

    AcknowledgementsThe authors thank Dr. Tom Black for funding part of this project and EPSRC for support under Grant number EP/I012400/1; Prof. A. Kirkland and Dr. J. Kim for the support on the 2200 microscope.IntroductionAtom probe tomography is increasingly used to investigate the microstructure of both conducting and non-conducting solid…[Read more]

  • Brin Beyer posted an update 3 months ago

    140 patients were enrolled (experimental: 53, control: 87). Mean age was 56.6 and 55.5 years, respectively. Patient’s BMI, stone laterality, stone location, and percentage of male patients were similar in both groups. The mean stone size was 0.84cm vs. 0.76cm (p = 0.243). The operation duration was 58.8 vs. 49.2 min (p = 0.022). The stone free…[Read more]

  • Brin Beyer posted an update 3 months ago

    The report established the city parks’ state of disrepair and the public’s desire for parks for recreation, before it Cardiogenol C outlined a three-pronged improvement strategy, involving the adoption of more accountable and “visionary” leadership, closer partnerships between the public and private sectors, and increased funding gained not p…[Read more]

  • Brin Beyer posted an update 3 months ago

    Cárcel et al. [37] designed a convective drier modified to apply power ultrasound, as shown in Fig. 1. The conventional drying chamber was replaced by an aluminum vibrating cylinder (internal diameter 100mm, height 310mm and 10mm thickness) driven by a piezoelectric composite transducer generating a high-intensity ultrasonic field inside the…[Read more]

  • Brin Beyer posted an update 3 months, 1 week ago

    IntroductionImmune dysfunction is a well-recognized sequela of equine pituitary pars intermedia dysfunction (PPID) that often manifests as opportunist bacterial infections (Schott, 2002; McFarlane, 2011, 2014). The mechanisms responsible for immune deficiency in PPID are unknown. It has previously been suggested that high serum or tissue orexin…[Read more]

  • Brin Beyer posted an update 3 months, 1 week ago

    In a broad sense, sustainability involves both concepts and strategies that are closely interdependent. From my personal experience in teaching green chemistry in master and doctorate programs, I use to show a slide (Table 1) that summarizes the basic premises in search for a safer chemistry and/or safer alternatives to current synthetic…[Read more]

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