Charles Bojsen

  • Charles Bojsen posted an update 4 weeks ago

    Because of its surface exposure, its immunogenicity, and the critical roles it plays during target-cell infection, gp120 has been a natural target for alkaline phosphatase inhibitor development since the early days of HIV-1 research (Burton and Mascola, 2015; Mascola and Haynes, 2013). This, however, has proven to be far from straightforward,…[Read more]

  • Charles Bojsen posted an update 4 weeks ago

    The SHMV movement protein localizes to the endoplasmic reticulum and interacts with plasmodesmata, which allows the formation of an ER bridge between cells, enabling virus cell-to-cell movement (Heinlein et al., 1998; Lucas, 2006; Más and Beachy, 1999). We hypothesized this as the reason why we observe a greater degree of VLP yield when both…[Read more]

  • Charles Bojsen posted an update 1 month ago

    ResultsDiscussionHPV induced carcinogenesis relies on the continued expression of E6 and E7 (Yoshinouchi et al., 2003). This, in turn, regulates a plethora of signal transduction pathways leading to the transformation and immortalisation of the cell.The ability of E6 to induce the degradation of its cellular partners has been proposed to be one of…[Read more]

  • Charles Bojsen posted an update 1 month ago

    The outbreak of the conflict in 1999After the First Russian-Chechen War (1994–1996) – the military reaction of the Kremlin to the unilaterally declared independence of what was then known as the Chechen Republic of Ichkeria (CRI) – the region was plunged into a deep depression caused by the ravages of the conflict, the consequent increase in crime…[Read more]

  • Charles Bojsen posted an update 1 month ago

    Further comprehensive analysis of the high-level functions of proteins in the three developmental stages in T. spiralis by KEGG showed that all the identified proteins were predicted to be involved in 250 pathways. The oocyte meiosis is a specialized type of cell division in which one round of DNA replication is followed by two meiotic divisions…[Read more]

  • Charles Bojsen posted an update 1 month ago

    Serological tests for Johne’s disease have low sensitivity but reasonable specificity. Testing of individual milk specimens yielded a sensitivity of 28% (Collins et al., 2005), slightly higher than serum, and sensitivity increased with age of animal tested (Nielsen et al., 2013). PCR can also be used to test for the presence of MAP DNA in milk (…[Read more]

  • Charles Bojsen posted an update 1 month ago

    Multivariate analysis results indicated that only age at primary THA is positively associated with short-term revision. Several factors might contribute to this finding. Some studies have shown that older patients had a higher risk of short-term failure, such as loosening, instability, and infection, compared to younger patients. A previous report…[Read more]

  • Charles Bojsen posted an update 1 month ago

    Infection with PEDV induces neutralizing antibody responses within 14–21 days post-infection, with NA titers in convalescent polyclonal serum usually ranging between 1:20 to 1:320 (Chen et al., 2016; Clement et al., 2016). As shown in Fig. 3, most S-specific mAbs produced here (exception SD33-1) were capable of completely blocking PEDV i…[Read more]

  • Charles Bojsen posted an update 1 month ago

    The CTX-M-79-lactamase had been previously detected in human clinical E. coli isolates (Tian et al., 2014), in bovine E.coli isolates (Wittum et al., 2010) as well as from Enterobacteriaceae isolates from rivers and lakes (Zurfluh et al., 2013). Our previous study found this lactamase in E.coli from fish (Jiang et al., 2012) and in the present…[Read more]

  • Charles Bojsen posted an update 1 month ago

    Similar to the effect of varied volume of yeast used, presented in Table 4, the mineralocorticoid receptor antagonists contents were unaffected by variations in fermentation periods, as shown in Table 5, while the amount of reducing sugars continuously increased with increment in fermentation period from 24h to 96h. No significant change in…[Read more]

  • ResultsDiscussionHypermucoviscous K. pneumoniae infection was common in New Zealand sea lion pups that were found dead on Enderby Island between 2006/07 and 2009/10, being present in 58% of pups examined. Castinel et al. (2007) examined cumulative death rates in New Zealand sea lion pups at the same location from 2000/01 to 2003/04, and found that…[Read more]

  • Materials and methodsDiscussionMay–Thurner syndrome is a condition of venous return insufficiency caused by hippo signaling of the left common iliac vein by the right common iliac artery. Two factors are responsible for the partial obstruction of the vein by the overlying artery: the anatomic orientation of the artery, with subsequent physical e…[Read more]

  • Last but not least, the authors also highlighted emerging alternative therapies. One of the examples included the modulation of interaction between B lymphocyte stimulator (BLyS) and BLyS receptor 3, which maintains the maturation and survival of B cells in the periphery. The modulation of B cell signalling using a small molecule inhibitor,…[Read more]

  • DiscussionThis study showed that thyrotropin receptor metformin significantly improved IR and BMI, especially in overweight and IR women affected by PCOS. Our results support the recommendations advocated by the 2013 Endocrine Society Clinical Guideline, which indicates that for women with PCOS, metformin is recommended for overweight, IR, or IGT…[Read more]

  • For North Island regions where the environmental suitability is much more heterogeneous: Gisborne, Hawke’s Bay, Manawatu and Wellington then these regions will probably be endemically unstable (Table 3). In endemically unstable areas the exposure to infected ticks is highly variable, leading to naïve cattle often being infected as adults rather th…[Read more]

  • ResultsDiscussionWe recently reported that PsV of diverse PV types exhibited no selectivity in early events of infection at either mucosal or squamous epithelial sites, strongly implying that downstream post-entry events are responsible for the observed differences in PV tissue tropism (Handisurya et al., 2012). Specifically, we found that murine…[Read more]

  • Indeed, we are. To return to the observations earlier in this paper from Gerschenkron about “backwardness” and policy adaptation, in this instance we see a state borrowing a foreign practice and adapting to it in such a way that serves and strengthens the state. It includes the basic ikk inhibitor of the original concept (e.g. elections) but it…[Read more]

  • ROS can also affect vascular tone by releasing prostanoids via COX-dependent pathways (Rodriguez-Martinez et al., 1998). Oxidative stress up-regulates both the constitutive and inducible isoforms of COX in smooth muscle (Shi and Vanhoutte, 2008) and COX, in turn, may generate ROS and/or metabolites of arachidonic acid, which could account for the…[Read more]

  • In this study we evaluated the efficacy of the Ad5-vectored subunit vaccine that delivers FMDV O1 Manisa trpv1 and capsid processing proteins (Ad5-O1Man) in swine. We also aimed to determine the minimum protective dose of this vaccine candidate and to predict its ability to induce adaptive immunity against different subtypes of FMDV serotype O.…[Read more]

  • Based on previously described information, no studies are available in the known literature regarding the prevalence of toxoplasmosis in cattle from the state of Rondônia, North region, Brazil. Because cattle toxoplasmosis represents a major importance for public health in general, the present study aimed to determine the seroprevalence of T.…[Read more]

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